NXP001 (aprepitant) – Oncology – Phase 1 ready

NXP001 is our new form of the drug aprepitant that is currently marketed as a product in the oncology supportive care setting

  • Aprepitant has a number of known properties, notably the NK-1 receptor that is involved in cellular responses
  • Literature data suggests that aprepitant could have benefits in oncology, i.e., beyond the currently marketed indications. For example, it has shown antiproliferative properties in tumoral cell lines of glioma, neuroblastoma, retinoblastoma, pancreas, larynx, colon, and gastric carcinoma1

A disadvantage of aprepitant is that its sub-optimal properties necessitate a complex formulation

  • We have discovered new forms of aprepitant (NXP001) with improved properties and we have granted patents on these

We have conducted preclinical studies and a Phase 1 study, which demonstrated bioavailability of NXP001, similar to the marketed product but without requiring a complex formulation

  • Further refinement of the formulation will be required ahead of initiating any future Phase 1 studies

Nuformix is currently pursuing licensing of NXP001

 

1Biological and Pharmacological Aspects of the NK1-Receptor